The Echinacea-derived immunostimulator and HIV-1 integrase inhibitor (À)-chicoric acid ( 2,3-bis{[3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]oxy}butanedioic acid; 1a) was conveniently prepared via a silanepromoted Pd-mediated chemoselective hydrogenolysis of its perbenzylated derivative 12a, which was
✦ LIBER ✦
Synthesis and Anti-HIV-1 Integrase Activitiy of Cyano Pyrimidinones
✍ Scribed by R. Ramajayam; Nilesh B. Mahera; Nouri Neamati; Mange Ram Yadav; Rajani Giridhar
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 385 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0365-6233
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## Abstract Coupling of 6‐benzyl‐5‐hydroxymethyluracil (**1**) with formaldehyde acetals followed by fluorination using (diethylamino)sulfur trifluoride (DAST) afforded 1‐alkenyloxymethyl and 1‐propargyloxymethyl 5‐fluoromethyl‐6‐benzyluracils **3a–c**. 6‐(3,5‐Dimethylbenzyl)‐5‐ethyl‐1‐[(2‐fluoroet