✦ LIBER ✦
Synthesis and Antagonistic Activity of Two Covalently Linked Dimers of Adrenocorticotropin-(11-24)-tetradecapeptide
✍ Scribed by Jean-Luc Fauchère
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- German
- Weight
- 432 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The chemical synthesis of two dimers of the sequence 11 to 24 of adrenocorticotropin is described. The two monomers were covalently linked through their N‐or C‐termini, respectively, using N‐acetylglutamic acid or lysine amide as spacers. Compared to the monomer, the first dimer showed moderately, the second strongly increased inhibitory potency upon steroidogenesis in isolated adrenal cells.