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Synthesis and analgesic activity of 4-amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-ones

✍ Scribed by Kaname Takagi; Masaaki Tanaka; Hikari Morita; Kuniyoshi Ogura; Katsuyuki Ishii; Naoki Nakata; Masayuki Ozeki

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
460 KB
Volume
22
Category
Article
ISSN
0223-5234

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The Schiff bases 3a-h obtained from 4-amino-1,2,4-triazol-3-ones 1a-h when subjected to Japp-Klingemann reaction yielded the corresponding 3-{2-[(2-aryl-5-methyl-3H-[1,2,4]-triazol-3-one-4-yl)]-iminophenyl}-pentane-2,4-diones 4 a-h. These diones on cyclisation with N 2 H 4 yielded the title compound