Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position

✍ Scribed by Yasuo Takano; Futoshi Shiga; Jun Asano; Naoki Ando; Hideharu Uchiki; Tsuyosi Anraku

• Book ID: 104364058
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 190 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00740-6

✦ Synopsis

The synthesis and biological properties of a novel class of 7-heterocycle-substituted quinoxalinecarboxylic acids, which bear a substituted phenyl group through a urethane linkage at the C-7 position, are described. One of the synthesized compounds, 15l, which has a 4-carboxyphenyl carbamoyloxymethyl imidazole group at the C-7 position and is water-soluble, was found to possess high potency in vitro and showed excellent neuroprotective efficacy in vivo.