Synthesis and activity of proteasome inhibitors
โ Scribed by Dunn, Derek; Iqbal, Mohamed; Chatterjee, Sankar
- Book ID
- 126918655
- Publisher
- Informa plc
- Year
- 2013
- Tongue
- English
- Weight
- 324 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1475-6366
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๐ SIMILAR VOLUMES
Based on the peculiar spatial array of the active sites in the internal chamber of the multicatalytic proteasome, as derived from the X-ray structure of yeast proteasome, homo-and heterobivalent inhibitors were designed and synthesized to exploit the principle of multivalency for enhancing inhibitio
## Abstract The ubiquitinโproteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and exampl