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Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2

✍ Scribed by Cesare Giordano; Anna Sansone; Annalisa Masi; Gino Lucente; Pasqualina Punzi; Adriano Mollica; Francesco Pinnen; Federica Feliciani; Ivana Cacciatore; Peg Davis; Josephine Lai; Shou-Wu Ma; Frank Porreca; Victor Hruby


Book ID
108116474
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
379 KB
Volume
45
Category
Article
ISSN
0223-5234

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Synthesis and Analgesic Activities of En
✍ Zhi-Hao Shi; Yun-Yang Wei; Chuan-Jin Wang; Li Yu πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 110 KB

## Abstract Endomorphin‐2 (**1**; H‐Tyr‐Pro‐Phe‐Phe‐NH~2~; EM2) and its novel cyclic asparagine (__cyclo__Asn) analogues, H‐Tyr‐__c__Asn(CHPh)‐Phe‐Phe‐NH~2~ (**2**) and H‐Tyr‐__c__Asn(CHMe~2~)‐Phe‐Phe‐NH~2~ (**3**), were synthesized __via__ liquid‐phase synthesis. The structures of the products and