Synthesis and Absolute Stereochemistry of a Constitutionally New Spiroacetal from an Insect
✍ Scribed by Hayes, Patricia; Fletcher, Mary T.; Moore, Christopher J.; Kitching, William
- Book ID
- 126852652
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 74 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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Spirangiens A (1, Scheme 1) and B (2), [1] isolated by the research group of Höfle from the epothilone-producing myxobacterium Sorangium cellulosum (strain So ce90), are polyketide metabolites [2] that possess potent antifungal and cytotoxic activity (IC 50 0.7 ng mL À1 against L929 mouse fibroblast
## Abstract The first enantioselective synthesis of two new monoterpene aldehyde‐esters from __Bupleurum gibraltaricum__, starting from an enantiopure building block, is described. The key step is a strictly controlled esterification to afford the somewhat unstable target compounds. The previously