𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis, Analgesic and Antiinflammatory properties of Certain 5-/6-Acyl-3-(4-substituted-1-piperazinylmethyl)-2-benzoxazolinones Derivatives

✍ Scribed by Meriç Köksal; Nesrin Gökhan; Esra Küpeli; Erdem Yesilada; Hakkı Erdoğan

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
110 KB
Volume
338
Category
Article
ISSN
0365-6233

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of a novel series of Mannich bases of 5‐/6‐acyl‐5‐methyl‐2‐benzoxazolinones has been described. The structures attributed to compounds 2a, 3a, 4a, 4b, 9a, 9b, 5a–5g, 6a–6g, 10a, 10g, 11a, 11g have been elucidated using IR and ^1^H NMR spectroscopic techniques besides elemental analysis. The compounds have been evaluated for their in vivo analgesic and antiinflammatory activities using the p‐benzoquinone‐induced writhing test and the carrageenan hind paw oedema test in mice, respectively. In addition, the ulcerogenic effects of the compounds were determined. Among the tested derivatives most promising results were obtained for the compounds bearing a 6‐(4‐chlorobenzoyl) at C‐6 position and 2‐/4‐fluorophenyl at C‐3 position of 2‐benzoxazolinone ring (11c, 11d).

📜 SIMILAR VOLUMES

Simple Synthesis of 2-Substituted 2-Oxaz
Simple Synthesis of 2-Substituted 2-Oxazolines and 5,6-Dihydro-4H-1,3-oxazines
✍ Dr. Helmut Witte; Dr. Wolfgang Seeliger 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

application may be in medicine where it might be possible to form three dimensional images of biological structures assuming that the problems associated with the transmission of sound in tissue can be solved. The fact that systems for use in acoustical holography are rapidly becoming all-electroni