Synthesis, aggregation properties, and antiprotozoal activity of heterocyclic heterogemini surfactants

✍ Scribed by M. Lukáč; L. Timko; M. Mrva; F. Ondriska; J. Karlovská; J. Valentová; I. Lacko

• Book ID: 102233737
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 210 KB
• Volume: 21
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20587

✦ Synopsis

Abstract

A series of four heterogemini surfactants have been synthesized: 2‐decyl [dodecyl(dimethyl)ammonio]ethyl phosphate, decyl 2‐(1‐dodecylpyrrolidinio‐1‐yl)ethyl phosphate, decyl 2‐(1‐dodecylpiperidinio‐1‐yl)ethyl phosphate, and decyl 2‐(1‐dodecylmorpholinio‐1‐yl)ethyl phosphate. Antiprotozoal activity of prepared compounds against Acanthamoeba lugdunensis was investigated. Decyl 2‐(1‐dodecylpyrrolidinio‐1‐yl)ethyl phosphate exhibited the best trophocidal activity. The activities of heterogemini surfactants were compared with their aggregation properties. © 2010 Wiley Periodicals, Inc. 21:203–209, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20587