Stereoselective synthesis of the imidazo
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A. Noordam; L. Maat; H. C. Beyerman
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Article
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2010
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Elsevier Science
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English
⚖ 727 KB
## Abstract A novel synthesis of (+)‐pilocarpine (**10a**) is described. L‐Histidine is converted into methyl (R)‐2‐bromo‐3‐(l‐methyl‐5‐imidazolyl)propionate (**5**) in which the configuration has been inverted. Alkylation of dibenzyl ethylmalonate with 5 yields the imidazole compound **6**, again