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Syntheses of radioactive and stable isotope-labelled 1-ethyl-6,7-methylenedioxy-4(1h)-oxocinnoline-3-carboxylic acids (cinoxacin)

✍ Scribed by T. Nagasaki; Y. Katsuyama; H. Minato

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
734 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐Ethyl‐6,7‐methylenedioxy‐4(1H)‐oxocinnoline‐3‐carboxylic acid (cinoxacin) (1), an effective antimicrobial agent has been labelled with carbon‐14. The carbon‐14 was incorporated into the C‐4 position of the molecule to give XIV in 10.0% overall radiochemical yield based on barium carbonate‐^14^C. The ^13^C‐, ^15^N‐, and d‐labelled compounds (XV, XVII, and XVIII) have also been synthesized for absorption and metabolism studies.

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