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Syntheses of C-1 Axial Derivatives of l -Menthol

✍ Scribed by Dillner, Debra K.


Book ID
120066016
Publisher
Taylor and Francis Group
Year
2009
Tongue
English
Weight
168 KB
Volume
41
Category
Article
ISSN
0030-4948

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C(l)-substituted (-)-menthone derivatives 3 were prepared by the stereoselective addition of the alkenyllithium reagents 9 to menthone (8) and subsequent acid catalyzed hydrolysis of the dioxolane protecting groups. Conjugate addition of cuprate reagents to enones 3a,b followed by a methanol quench