Syntheses of 5′-deoxy-5-[18F] fluorouridine and related compounds as probes for measuring tissue proliferation in vivo
✍ Scribed by Chyng-Yann Shiue; Alfred P. Wolf; Morris Friedkin
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 336 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Biology Department, U n i v e r s i t y of C a l i f o r n i a , San Diego, L a J o l l a , CA ** A r a p i d s y n t h e s i s of 5'-deoxy-5-[ 1 8 F ] f l u o r o u r i d i n e (?_a) from e i t h e r
a c i a l acetic a c i d at room temperature followed by h y d r o l y s i s with sodium methoxide i n methanol g i v e s 5'-deoxy-5-[ I8F J f l u o r o u r i d i n e (2.) i n radiochemical y i e l d s of 20-25% i n a s y n t h e s i s t i m e of 80 min from EOB. The same method a l s o has been used t o s y n t h e s i z e 5-[18F]fluorouridine (2) and 2'-deoxy-5-[ 18F]fluorouridine (s) in similar radiochemical y i e l d s . h y p o f l u o r i t e (CH3C02F) is proposed as an i n t e r m e d i a t e f o r t h e s e r e a c t i o n s . F l u o r i n a t i o n of 2' ,3'-di-:-acetyl-Acetyl