Syntheses of 2,4,6-trihydroxy-, 2,4,6-trihydroxy-5-methyl- and 2,4,5,6-tetrahydroxy-substituted 3-(3-phenylpropionyl)benzaldehydes and their bactericidal activity
✍ Scribed by Shingo Sato; Heitaro Obara; Hiroto Takeuchi; Takashi Tawaraya; Akira Endo; Jun-Ichi Onodera
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 181 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0031-9422
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## Abstract The ^13^C‐labelled putative erythromycin biosynthetic intermediates, ((2__S__,3__S__,4__S__,5__R__,6__R__,7__R__)‐3,6,7‐trihydroxy‐2,4,6‐trimethyl[1‐^13^C]nonan‐5‐olide and __S__‐2‐acetylaminoethyl (2__R__,3__S__,4__S__,5__R__,6__S__,7__R__)‐3,5,6,7‐tetrahydroxy‐2,4,6‐trimethyl[1‐^13^C]
Z-Substituted-1,2,3,4,5,6-hexahydro-3-bemwxine-4, 6diones(la-d) and 2-methoxy-2,5,6,7-tetrahydro+ benxamnine-1,3dione 8 were synthesii thro@ an oxklative ring expansion reaction of 6-methylthio-7-substiituted-benzo(a] octem (2a-d ) and 7-methylthio%-methoxy-benzo[a]nonem 7 with sodium periodate in i