𝔖 Bobbio Scriptorium
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Syntheses of 2-amino- and 2-(benzylamino)-2-deoxyheptonic acids

✍ Scribed by Juan A. Galbis Pérez; Juan C. Palacios Albarrán; Emilio Román Galán


Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
380 KB
Volume
114
Category
Article
ISSN
0008-6215

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Diastereoselective alkylation of (R)-(+)-camphor-based glycine or alanine esterimines with 3bromo-2-fluoropropene after hydrolytic deprotection gave (R)-(+)-2-amino-4-fluoropent-4-enoic acid with 38% overall yield and 90% ee, or (R)-(+)-2-amino-4-fluoro-2-methylpent-4-enoic acid (19% overall yield,