Syntheses of 1,3-disubstituted imidazo[l,5-a]pyridines

✍ Scribed by A.Paul Krapcho; John R Powell

• Book ID: 104217976
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 107 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)83860-5

✦ Synopsis

Facile syntheses of 1,3-disubstituted imidazo[l,5-alpyridines have been effected by treatment of ketimines derived from di-2-pyridyl ketone with LDA and benzophenone, reactions of benzyl amine with di-2-pyridyl ketone in boron trifluoride etherate, and reaction of di-2-pyridyl methanamine imines with molecular sieves in benzene.

We wish to report several facile synthetic routes to 1,3-disubstituted imidazo [l,5-a] pyridines Lwhich were uncovered during a study of the regiochemistry of electrophilic attack on anions derived from N-alkyl diarylketimines.