Chemical stability, enzymatic hydrolysis
Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
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Chun Yang; Hongwu Gao; Ashim K. Mitra
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Article
📅
2001
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John Wiley and Sons
🌐
English
⚖ 183 KB
👁 1 views
The objective of this work was to improve nasal absorption of relatively impermeable small drug molecules via an amino acid prodrug approach. Acyclovir was selected as a model drug. L-Aspartate beta-ester, L-lysyl, and L-phenylalanyl esters of acyclovir were synthesized to investigate their effectiv