𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Syntheses and fluorescent properties of 2-amino substituted 6,7-dimethoxy-4-(trifluoromethyl)quinolines

✍ Scribed by Wolfgang Stadlbauer; Appasaheb B. Avhale; Naresh S. Badgujar; Georg Uray

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
151 KB
Volume
46
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

2‐Amino‐substituted 6,7‐dimethoxy‐4‐trifluoromethyl‐quinolines were synthesized from the 2‐oxo compound 1 via 2‐chloroquinoline 2 and aminated with anilines or benzylamine to give highly fluorescent molecules 4, 5. 2‐Aminoquinoline 8 was obtained via azidation of 2, 3, 3a, 3b, 3c, 4, 4a, 4b, 4c, 5, 6A, 6T, reaction to the phosphazene 7, and hydrolysis. 4‐Ethoxycarbonyl derivative 4b is suitable for linking appropriate biomolecules. The construction of a linking group was achieved by conversion of 4b via carboxylic acid 9 to the reactive O‐succinimide ester 10, which reacts easily with amino acids or peptides to amides 11 and 12. The fluorescent properties were investigated and are comparable with derivatives of 1. J. Heterocyclic Chem., (2009).

📜 SIMILAR VOLUMES

ChemInform Abstract: Syntheses and Fluor
ChemInform Abstract: Syntheses and Fluorescent Properties of 2-Amino Substituted 6,7-Dimethoxy-4-(trifluoromethyl)quinolines.
✍ Wolfgang Stadlbauer; Appasaheb B. Avhale; Naresh S. Badgujar; Georg Uray 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 28 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Regiospecific Synthesis of 4-Alkoxy and
Regiospecific Synthesis of 4-Alkoxy and 4-Amino Substituted 2-Trifluoromethyl Pyrroles.
✍ Nilo Zanatta; Juliana M. F. M. Schneider; Paulo H. Schneider; Ana D. Wouters; He 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.