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Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[18F]fluoroethoxyestradiol for positron emission tomography

✍ Scribed by Jiyoung Mun; Yuefang Wang; Ronald J. Voll; Daniel Escuin-Borras; Paraskevi Giannakakou; Mark M. Goodman


Book ID
116799226
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
377 KB
Volume
35
Category
Article
ISSN
0969-8051

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Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with