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Syntheses and Antiproliferative Activities of 7-Azarebeccamycin Analogues Bearing One 7-Azaindole Moiety

✍ Scribed by Marminon, Christelle; Pierré, Alain; Pfeiffer, Bruno; Pérez, Valérie; Léonce, Stéphane; Joubert, Alexandra; Bailly, Christian; Renard, Pierre; Hickman, John; Prudhomme, Michelle


Book ID
121242302
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
350 KB
Volume
46
Category
Article
ISSN
0022-2623

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Synthesis of isogranulatimides A and B a
✍ Bernadette Hugon; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 269 KB

The synthesis of a new family of isogranulatimides analogues is described in which a 7-azaindole replaces the indole moiety. The key step is the photocyclization of the aza didemnimide intermediates which leads to two isomeric analogues of isogranulatimides A and B. A derivative bearing a carbohydra