Synthese von Salm-Calcitonin, einem hochaktiven hypocalcämischen Hormon. Vorläufige Mitteilung

✍ Scribed by St. Guttmann; J. Pless; R. L. Huguenin; Ed. Sandrin; H. Bossert; K. Zehnder

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: German
• Weight: 318 KB
• Volume: 52
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19690520702

✦ Synopsis

A total synthesis of salmon calcitonin is described. The C-terminal nonapeptide amide 24-32 was coupled with the heptapeptide 17-23. The resulting hexadecapeptide aniide 17-32 was reacted with the heptapeptide 10-16 to give the tricosapeptide 10-32. This was condensed with the N-terminal nonapeptide 1-9, yielding the protected dotriacontapeptide amide 1-32. After removal of the protective groups and purification by gel-filtration the free peptide obtained cxhibited the physical, chemical and biological properties of the natural hormone. Its hypocalcaemic activity (ca. 3500 MRC Ujmg) is 20-30 times higher than that of porcine or human calcitonin.