✦ LIBER ✦
Synthese von Catechol-O-methyl-transferase-hemmenden Verbindungen. In den Catecholaminmetabolismus eingreifende Substanzen. 1. Mitteilung
✍ Scribed by A. Carlsson; M. Lindqvist; S. Fila-Hromadko; H. Corrodi
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- German
- Weight
- 439 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The synthesis of a series of compounds with the general structure shown in formula I is described. These compounds, especially 3, 4‐dihydroxyphenylacetamide (XVI), are potent and nontoxic inhibitors in vivo of catechol‐O‐methyl transferase. They compare favourably with pyrogallol and other known inhibitors of this enzyme.