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Synthese von 4′-Azido-3′,5′-ditritio-L-phenylalanin-peptiden als « Photo-affinitätsproben » für Ligand-Rezeptor-Wechselwirkungen. Vorläufige Mitteilung

✍ Scribed by Walter Fischli; Mario Caviezel; Alex Eberle; Emanuel Escher; Robert Schwyzer


Publisher
John Wiley and Sons
Year
1976
Tongue
German
Weight
112 KB
Volume
59
Category
Article
ISSN
0018-019X

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✦ Synopsis


The Synthesis of 4′‐Azido‐3′,5′‐ditrito‐L‐phenylalanine Peptides as « Photoaffinity Probes » for Ligand‐Receptor Interaction

The synthesis of L‐p‐azido‐phenylalanine and peptides thereof containing tritium atoms in the m,m′‐positions of the phenyl ring is described. Starting materials are L‐p‐amino‐phenylalanine and L‐p‐amino‐m,m′‐diiodo‐phenylalanine. Such peptides are being used for specific photoaffinity labelling of receptor and enzyme molecules.