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Synthese neuartiger triazoloanellierter 8-Azapurine

✍ Scribed by Ried, Walter ;Laoutidis, Joannis

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 270 KB
Volume: 1988
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.198819881118

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✦ Synopsis

Treatnicnt of the S-amino4-cyano-l.2.3-triazoles I a-I with I tricthyl orthoformatc and orthoacctatc 2 gives the cthoxymctiiylcncamino-~,2,3-tna~oics 3a -f which react with hydrazinc hydrate at rocmi tcniperaturc to yield thc l-amino-6-imino-8-a7apurincs 411-f. Thc pyriniidincs 6a-I arc obtaincd from J a -f by reaction with tricthyl orthoacetate and orthoformate 5.

8-Azapurine sind aufgrund ihrer Ahnlichkeit mit den Purinen von groljem pharmakologischem Interesse2

). Im Rahmen unserer Arbciten konnten wir neue Vertreter dieser Substanzklasse herstellen und als Bausteine in der Heterocyclen-Synthese einsetzen. Die Aminonitrile la-f3' reagieren mit den Orthoestern 2 zu den Imidsaureestern 3a-f4).

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