Synthese für optisch aktive (6R)-substituierte (5R) carbapeneme

✍ Scribed by W Koller; A Linkies; H Pietsch; H Rehling; D Reuschling

• Book ID: 104220653
• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 210 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87154-3

✦ Synopsis

The synthesis of an enantiomerically pure (5R, 6R)-carbapenem z is described. The key step consists of a stereospecific C-C-coupling in I-position of the lactam 9 by means of cuprates.