Synthese einiger 14C-signierter Dioxo-diäthyl-hydro-pyridine und Untersuchungen über deren Verteilung, Verweilzeit und Ausscheidung bei der Ratte

✍ Scribed by Karl Bernhard; G. Brubacher; A. H. Lutz

• Publisher: John Wiley and Sons
• Year: 1954
• Tongue: German
• Weight: 926 KB
• Volume: 37
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19540370630

✦ Synopsis

By alkylation of the pyrazole derivatives obtained from disubstituted cyano-acetic acid esters and hydrazine (formula 1) a, series of l-alkyl-3-amino-4,4-disubstituted-5-oxo-pyrazolines (7) was obtained. These were further alkylated to 1,a-dialkyl derivatives (8). From the compounds 1 the 5-halogenated iminopyrazolines 9 were obtained with POCl, or PBr,. The 4-methyl-4-n-butyl-5-bromo derivat,ive of this series has valuable sedative properties. Catalytic dehalogenation with Pd/H, gave 3-imino-4,4-dialkyl pyrazolines 10. The acylation of the different types of compounds was studied.