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Synthese eines hochwirksamen Hypertensin II-amids (L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanin)

✍ Scribed by W. Rittel; B. Iselin; H. Kappeler; B. Riniker; R. Schwyzer

Publisher
John Wiley and Sons
Year
1957
Tongue
German
Weight
788 KB
Volume
40
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The synthesis of Ileu^5^‐hypertensin II‐Asp‐β‐amide, L‐Asparaginyl‐L‐arginyl‐L‐valyl‐L‐tyrosyl‐L‐isoleucyl‐L‐histidyl‐L‐prolyl‐L‐phenylalanine, is described. The highly purified octapeptide is 5 to 10 times as active as noradrenaline on the blood pressure of the rat in the experimental set‐up of Peart^9^), and 2 to 4 times as active as Val^5^‐ hypertensin I, isolated from bovine plasma^3^).

📜 SIMILAR VOLUMES

Synthese hochwirksamer Dekapeptide mit d
Synthese hochwirksamer Dekapeptide mit der Aminosäuresequenz des Val5-Hypertensins I (L-Asparagyl-L-arginyl-L-valyl-L-tyrsyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucin und L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucin)
✍ R. Schwyzer; B. Iselin; H. Kappeler; B. Riniker; W. Rittel; H. Zuber 📂 Article 📅 1958 🏛 John Wiley and Sons 🌐 German ⚖ 906 KB

## Abstract The preliminarily published synthesis(^4^) of decapeptides with the amino acid sequence of Val^5^‐hypertensin I has been repeated several times. The products showed a high hypertensive activity, comparable with that of the corresponding octapeptides [Val^5^‐hypertensin II and Val^5^‐hyp