✦ LIBER ✦
Synthese der diastereomeren 4-Amino- und 4-Hydroxy-3-(p-chlorphenyl)-valeriansäuren. Kristallstruktur von cis-4-(p-bromphenyl)-5-methyl-2-pyrrolidinon
✍ Scribed by Hans Bruderer; Wolf Arnold; Willy E. Oberhänsli
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- German
- Weight
- 654 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Synthesis of 4‐amino‐ and 4‐hydroxy‐3‐(p‐chlorophenyl)‐valeric acids. X‐ray structure of cis‐4‐(p‐bromophenyl)‐5‐methyl‐2‐pyrrolidinone
The syntheses of diastereomeric 4‐amino‐ and 4‐hydroxy‐3‐(p‐chlorophenyl)‐valeric acids and of their ring closure products (lactones and lactams), starting from 3‐(p‐chlorophenyl)‐4‐oxo‐valeric acid, are described. A single‐crystal X‐ray structure analysis of cis‐4‐(p‐bromophenyl)‐5‐methyl‐2‐pyrrolidinone is given. Some aspects of the biochemistry of threo‐3‐(p‐chlorophenyl)‐4‐amino‐valeric acid are presented.