The carbonation with lPCO2 of the lithium derivative 6 prepared from p-chtorcdiphenytmethane 5 and n-but 1 lithium in THF i n presence of tetramethylmediamine gives (~4C-carbozyt) 2-I -chi!oro phenyll-2-phenylacetic acid 7 with 85 X yield based on d04. Action of thionyl chloride gave the correspond
Synthese de la Letosteine: Marquee AU 14C ET AU 35S
✍ Scribed by Colette Nicolas; Francloise Gachon; Michel Faurie
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 354 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
LETOSTEINE, 2-[ l ( e t h o x y c a r b o n y l m e t h y l t h i o ) -e t h y l 1 4 -h y d r o x y c a r b o n y l t h i a z o l i d i n e i s l a b e l l e d w i t h e i t h e r carbon-14 o r S u l f u r -3 5 on t h e f o l l o w i n g p o s i t i o n s : t h e c a r b o x y l i c c a r b o n o f t h e ester f u n c t i o n b y means t h e t h i a z o l i d i n y l g r o u p b y means o f L-( 'S) -c y s t e i n e .
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