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Syntehsis and structural stability of helichrome as an artificial hemeproteins

✍ Scribed by Tomikazu Sasaki; Emil Thomas Kaiser

Publisher: Wiley (John Wiley & Sons)
Year: 1990
Tongue: English
Weight: 765 KB
Volume: 29
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360290112

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✦ Synopsis

A detailed procedure is described for the synthesis of helichrome, which is the first successful example of polypeptide-based artificial hemeprotein. The segment synthesiscondensation approach used for the assembly of small proteins has proven to be extremely useful for protein mimetics as well. The final deprotection was performed using the TMSOTf-thioanisole method instead of the less-convenient hydrogen fluoride method. The unfolding transition of the a-helical conformation of helichrome induced by guanidine hydrochloride was studied to understand the stability and dynamics of the folded structure. The resulting parameters (C,., = 5.2M and AGHZo = -4.4 kcal mol-* I characterizing helichrome denaturation were comparable to that of native globular proteins.

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