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Synovial sarcoma of the head and neck: Chromosomal translocation (X;18) as a diagnostic aid

✍ Scribed by Robert A. Cihak; William M. Lydiatt; Daniel D. Lydiatt; Julia A. Bridge

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 96 KB
Volume: 19
Category: Article
ISSN: 1043-3074
DOI: 10.1002/(sici)1097-0347(199709)19:6<549::aid-hed14>3.0.co;2-0

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✦ Synopsis

Background. Synovial sarcoma, a rare tumor in the head and neck, has been historically diagnosed by its characteristic biphasic histologic pattern. Monophasic variants exist which can be difficult to diagnose.

Methods. Two cases of synovial sarcoma of the head and neck are presented. In both cases, cytogenetic analysis was performed using standard protocols.

Results. Both tumors demonstrated a chromosomal translocation, t(X;18)(p11.2;q11.2), which either made or confirmed the diagnosis.

Conclusions. Synovial sarcoma contains a characteristic chromosomal translocation which is a useful diagnostic tool, especially when histologic studies are equivocal.

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