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SYNERGISTIC REGULATORY EFFECTS OF TNF α, IL-1 αAND IFN α ON THE GROWTH AND DIFFERENTIATION OF DAUDI LYMPHOMA CELLS

✍ Scribed by E. SANTAVENERE; R. DI PIETRO; M.A. CENTURIONE; L. DI DOMENICANTONIO; O. TRUBIANI; R.A. RANA

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
969 KB
Volume
20
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

The regulatory effects of the combined treatment of tumour necrosis factorα (TNFα), interleukin‐1α (IL‐1α) and interferonα(IFNα) on the growth and differentiation of Daudi lymphoma cells were investigated. By means of anti‐BrdU monoclonal antibodies and [^3^H‐thymidine] incorporation a reduced proliferation rate was shown both through a combi‐nation of TNFα with either IL‐1α or IFNα and, above all, through simultaneous treatment with the three cytokines. In parallel, the degree of differentiation was evaluated via morphological criteria and detection of Fc receptors (FcR) and appeared higher after treatment with the three cytokines. Our results provide evidence of the increased sensitivity of this cell line to this combined treatment supporting the existence of a synergistic interaction in inducing the antiproliferative and differentiative effects.

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