Synergistic killing effect of chloroquine and androgen deprivation in LNCaP cells
โ Scribed by Ramesh R. Kaini; Chien-An A. Hu
- Book ID
- 116303759
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 844 KB
- Volume
- 425
- Category
- Article
- ISSN
- 0006-291X
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๐ SIMILAR VOLUMES
## Abstract The therapeutic efficacy of Gemยฎ231, a second generation antisense molecule targeted to the RIฮฑ subunit of PKA~RIฮฑ~ (ASโPKA), administered in combination with androgen deprivation (AD) and radiation therapy (RT), was examined in androgen sensitive (LNCaP) and insensitive (PC3) cell line
## BACKGROUND. In an androgen-dependent manner, the androgen receptor (AR) binds to the androgen-responsive element (ARE) in the regulatory region of target genes. We hypothesize that an "ARE decoy," a double-stranded oligonucleotide containing the same DNA sequence as ARE, can inhibit prostatic p