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Synergistic interaction of variants inCHEK2andBRCA2on breast cancer risk

✍ Scribed by Pablo Serrano-Fernández; Tadeusz Dębniak; Bohdan Górski; Natalia Bogdanova; Thilo Dörk; Cezary Cybulski; Tomasz Huzarski; Tomasz Byrski; Jacek Gronwald; Dominika Wokołorczyk; Steven A. Narod; Jan Lubiński


Publisher
Springer US
Year
2008
Tongue
English
Weight
171 KB
Volume
117
Category
Article
ISSN
0167-6806

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Two ATM variants and breast cancer risk
✍ Deborah Thompson; Antonis C. Antoniou; Mark Jenkins; Anna Marsh; Xiaoqing Chen; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 1 views

The ATM gene is mutated in ataxia-telangiectasia (AT). Heterozygote female relatives of AT cases have a 2-7fold increased risk of breast cancer. We previously reported high risks of breast cancer associated with certain ATM variants. To estimate the risks more precisely, we have examined two ATM var