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Synergistic induction of cyclooxygenase-2 by gastrin and EGF in intestinal epithelial cells

✍ Scribed by Ji-Zhong Cheng; Yan-Shi Guo; Mark R. Hellmich; Courtney M. Townsend Jr

Book ID
119426929
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
185 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract Cyclooxygenase (COX)‐2 derived prostaglandins (PGs) play a major role in intestinal inflammation and colorectal carcinogenesis. Because COX‐2 is the rate‐limiting step in the production of PGs, mechanisms that regulate COX‐2 expression control PG production in the cell. Using the non‐tu