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Synergistic induction of CX3CL1 by interleukin-1β and interferon-γ in human lung fibroblasts: involvement of signal transducer and activator of transcription 1 signaling pathways

✍ Scribed by Takeo Isozaki; Kumiko Otsuka; Michihito Sato; Ryo Takahashi; Kuninobu Wakabayashi; Nobuyuki Yajima; Yusuke Miwa; Tsuyoshi Kasama

Book ID: 119383423
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 487 KB
Volume: 157
Category: Article
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2010.11.007

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It has previously been demonstrated that interleukin-1 (IL-I) is expressed in a variety of fibroblast cell lines. In this study, we investigated the mechanisms involved in the regulation of IL-1 p production by cultured human dermal fibroblasts. We have shown that IL-I p is constitutively expressed