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Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand

✍ Scribed by Tomohiko Ohno; Yohei Shirakami; Masahito Shimizu; Masaya Kubota; Hiroyasu Sakai; Yoichi Yasuda; Takahiro Kochi; Hisashi Tsurumi; Hisataka Moriwaki


Book ID
116335906
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
985 KB
Volume
323
Category
Article
ISSN
0304-3835

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## Abstract Hepatocellular carcinoma (HCC) is one of the deadliest forms of human liver cancer and does not respond well to conventional therapies. Novel effective treatments are urgently in need. G‐protein‐coupled kinase 2 (GRK2) is unique serine/threonine kinase that involves in many signaling pa