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Synergistic enhancement of the antiproliferative activity ofcis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C

โœ Scribed by Johann Hofmann; Florian Ueberall; Lydia Posch; Karl Maly; Dieter B. J. Herrmann; Hans Grunicke


Book ID
112773326
Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
701 KB
Volume
24
Category
Article
ISSN
0024-4201

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Enhancement of the antiproliferative eff
โœ Johann Hofmann; Wolfgang Doppler; Axel Jakob; Karl Maly; Lydia Posch; Florian รœb ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 769 KB

Quercetin (3,3',4',5,7-pentahydroxyflavone) has been shown to inhibit a variety of enzymes including the calcium- and phospholipid-dependent protein kinase (protein kinase C) in vivo and in vitro. We show that this compound synergistically enhances the antiproliferative activity of cis-diamminedichl