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Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression

✍ Scribed by Qunfang Li; Raymond M Esper; Jeffrey A Loeb

Book ID
116735203
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
813 KB
Volume
26
Category
Article
ISSN
1044-7431

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## Abstract Here we show that neuregulin‐2 (Nrg‐2) α‐ and β‐isoforms can activate acetylcholine receptor (__AChR__) transcription as surface‐attached ligands. More importantly, we demonstrate that Schwann cells that express Nrg‐2Ξ± on their cell surface, the same Nrg‐2 isoform expressed by terminal