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Synergistic effects of aspirin and butyrate on induction of p21CIP1/WAF1 expression

✍ Scribed by Kreth, Florian; Luehrs, Hardi; Kudlich, Theo; Schauber, Juergen; Kelber, Elisabeth; Krott, Kerstin; Scheppach, Wolfgang; Menzel, Thomas

Book ID: 123186447
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 195 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(00)84272-9

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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s