𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

✍ Scribed by Xu, R-H; Pelicano, H; Zhang, H; Giles, F J; Keating, M J; Huang, P


Book ID
110056489
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
200 KB
Volume
19
Category
Article
ISSN
0887-6924

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Inhibition of mammalian target of rapamy
✍ Nadine Darwiche; Ansam Sinjab; Ghada Abou-Lteif; Mirella Bou Chedid; Olivier Her πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 731 KB

## Abstract HTLV‐I‐associated adult T‐cell leukemia/lymphoma (ATL) and human T‐cell lymphotropic virus type I (HTLV‐I)‐negative peripheral T‐cell lymphomas carry poor prognosis mainly because of acquired resistance to chemotherapy. We have shown that this disease is responsive to the combination of

Longitudinal inhibition of PI3K/Akt/mTOR
✍ Takayuki Ikezoe; Chie Nishioka; Kentaro Bandobashi; Yang Yang; Yoshio Kuwayama; πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 1006 KB

This study found that phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling was activated in human T-cell lymphotropic virus type I (HTLV-1)-infected leukemia cells. Rapamycin (1-100 nM, 48 h), the inhibitor of mTOR and its analog RAD001 (1-100 nM, 48 h)-induced gro