Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
β Scribed by Xu, R-H; Pelicano, H; Zhang, H; Giles, F J; Keating, M J; Huang, P
- Book ID
- 110056489
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 200 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0887-6924
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This study found that phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling was activated in human T-cell lymphotropic virus type I (HTLV-1)-infected leukemia cells. Rapamycin (1-100 nM, 48 h), the inhibitor of mTOR and its analog RAD001 (1-100 nM, 48 h)-induced gro