Synergistic Effect of Cyclic AMP and Insulin on the Expression of Cyclin A Gene in Swiss 3T3 Cells
β Scribed by Yong Hee Lee; Joo-Seop Park; Chi Hye Park; Seung Ki Lee
- Book ID
- 115581842
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 624 KB
- Volume
- 244
- Category
- Article
- ISSN
- 0006-291X
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Addition of prostaglandin E1 (PGE1) to quiescent cultures of Swiss 3T3 cells rapidly elevates the intracellular levels of cAMP and increases the activity of adenylate cyclase in particulate fractions of these cells. In the presence of insulin, PGE1 stimulates the reinitiation of DNA synthesis. Both
## Abstract In order to develop a model system for identifying signaling pathways and cell cycle events involved in gastrinβmediated mitogenesis, we have used high efficiency retroviralβmediated transfection of cholecystokinin (CCK)~B~/gastrin receptor into Swiss 3T3 cells. The retrovirallyβtransfe