Effect of a xanthine analog on human hep
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L Marucci; L Varticovski; I M Arias
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Article
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1997
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John Wiley and Sons
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English
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Hepatocellular carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the multidrug-resistance efflux pump. A xanthine analog, 1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine (CT-2584,CTI), is cytotoxic to many tumors in culture and was four times