Synergistic Effect: Hydroalkoxylation of Allenes through Combination of Enantiopure BIPHEP-Gold Complexes and Chiral Anions

✍ Scribed by Kohsuke Aikawa; Masafumi Kojima; Koichi Mikami

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 202 KB
• Volume: 352
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000672

✦ Synopsis

Abstract

A synergistic effect is observed for the combination of a neutral dinuclear gold complex with a chiral silver phosphate in the intramolecular hyroalkoxylation of allenes to give furan derivatives in high yields and enantioselectivities. The monocationic dinuclear gold complex affords higher catalytic activity and enantioselectivity than the neutral or dicationic digold complexes. The synergistic effect is thus highly promising to provide a guiding principle in designing an efficient chiral environment for creating an asymmetric catalyst.