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Synergistic Cytotoxicity of Gemcitabine, Clofarabine and Edelfosine (± DNA alkylating agent) in Lymphoma Cell Lines

✍ Scribed by Valdez, Ben C.; Zander, Axel; Song, Guiyun; Murray, David; Nieto, Yago; Li, Yang; Champlin, Richard E.; Andersson, Borje S.


Book ID
122281224
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
53 KB
Volume
20
Category
Article
ISSN
1083-8791

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## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__