Progression to androgen independence remains the main obstacle to improving survival and quality of life in patients with advanced prostate cancer. Induction of differentiation may serve as a rational basis for prevention of progression to androgen independence by modulating gene expression activate
โฆ LIBER โฆ
Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model
โ Scribed by Simon Leung; Hideaki Miyake; Tobias Zellweger; Anthony Tolcher; Martin E. Gleave
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 111 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0020-7136
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We have reported that antisense Bcl-2 oligodeoxynucleotide (ODN) delays progression to androgen independence in the androgen-dependent (AD) mouse Shionogi tumor model. Here, we characterize changes in bcl-xL, another important anti-apoptotic gene, and test the efficacy of adjuvant antisense Bcl-xL O