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Synergistic antitumoral effect of the immunomodulator AS101 + paclitaxel (Taxol): Association with ras-dependent signal transduction pathways

✍ Scribed by B. Sredni; D.L. Longo; R. Catane; A. Shani; M. Albeck; Y. Kalechman

Book ID
114216565
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
14 KB
Volume
28
Category
Article
ISSN
0301-472X

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Synergistic anti-tumoral effect of pacli
Synergistic anti-tumoral effect of paclitaxel (taxol)+AS101 in a murine model of B16 melanoma: Association with ras-dependent signal-transduction pathways
✍ Yona Kalechman; Dan L. Longo; Raphael Catane; Adi Shani; Michael Albeck; Benjami 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 206 KB

Optimal doses of paclitaxel (Taxol) combined with the immunomodulator AS101, previously shown to have antitumoral effects, administered to B16 melanoma-bearing mice decreased tumor volume and resulted in over 60% cure. Paclitaxel؉AS101 directly inhibited the clonogenicity of B16 melanoma cells in a