๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synergistic antitumor activity of vincristine and VP-16-213

โœ Scribed by Don V. Jackson; Tony R. Long; Thomas F. Trahey; Timothy M. Morgan

Book ID
104693937
Publisher
Springer
Year
1984
Tongue
English
Weight
428 KB
Volume
13
Category
Article
ISSN
0344-5704

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โœฆ Synopsis

The potential interaction of the antitumor agents vincristine and VP-16-213 was investigated in vivo. DBA/2 mice were inoculated with 10(6) P388 murine leukemia cells, after which single IP injections of saline only, vincristine only, VP-16-213 only, or a combination of vincristine and VP-16-213 were administered. Long-term survival (greater than 60 days) was observed in 0/45, 1/45 (2%), 9/135 (7%), and 44/135 (33%) mice, respectively (P less than 0.001). Treatment was most effective when VP-16-213 was administered 0-72 h after vincristine. A similar trend was observed in mice bearing P1534 murine leukemia. These data demonstrate synergistic antitumor activity between vincristine and VP-16-213 in a murine model.

๐Ÿ“œ SIMILAR VOLUMES

Vincristine, adriamycin, cyclophosphamid
Vincristine, adriamycin, cyclophosphamide, and etoposide (VP16-213) in small-cell anaplastic carcinoma of the lung
โœ F. E. Eyben; ร…. Arwidi; C. Hellekant; K. Jonsson; S. ร…. Lindahl; W. Mattsson; L. ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Springer ๐ŸŒ English โš– 299 KB

Twelve patients with small-cell anaplastic carcinoma of the lung were treated with vincristine 1 mg/m2 i.v. day 1, adriamycin 50 mg/M2 i.v. day 1, cyclophosphamide 1,000 mg/m2 i.v. day 1, and etoposide 80 mg/m2 i.v. day 2, 4, 6 given on an outpatient basis and repeated at 3-week intervals. As consol