Synergistic anti-tumor effect of mini-cells prepared fromSalmonella typhimuriumwith mitomycin C in EL4-bearing mice

✍ Scribed by Satonori Kurashige; Kazue Kodama; Toshiharu Yoshida

• Publisher: Springer-Verlag
• Year: 1983
• Tongue: English
• Weight: 218 KB
• Volume: 14
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00205361

✦ Synopsis

A statistically significant increase in survival time was observed in EL4-bearing mice after a mini-cell inoculation. However, no case of survival for over 30 days was observed after an EL4 graft in mice treated with mini-cells alone. Fifty percent of the mice survived for 40 days after an EL4 transplantation when the mice were treated with both an IV injection of mini-cells and an SC injection of mitomycin C. The mini-cell injection restored the macrophage chemotaxis activity in EL4-bearing mice but did not restore the lymphocyte activities.