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Synergistic activation of rat hepatocyte glycogen phosphorylase by A23187 and phorbol ester

✍ Scribed by John N. Fain; Shih-Ying Li; Irene Litosch; Michael Wallace

Book ID
115758127
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
408 KB
Volume
119
Category
Article
ISSN
0006-291X

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The phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore, A23187, have similar effects on many different cells. For example, both show mitogenic and comitogenic activities for lymphocytes. It had been suggested that some of TPA's effects are due to its ab